Development of a continuous microfluidic system for the crystallization of pharmaceutical compounds


Abstract : Microfluidics offers a wide range of new tools that permit one to revisit the formation of crystals in solution and yield insights into crystallization processes, as for instance to acquire thermodynamic and kinetic data that may improve industrial processes and shed a new light on nucleation and growth mechanisms. A microfluidic chip thus allows fine tuning of control parameters for crystallisation, such as residence time, concentration, temperature constraint and Reynolds number. A special attention will thus be paid in this project on the influence of the flow (Reynolds number and channel topology) on the germination kinetics, since to our knowledge, no systematic study exists on that topic and because it has an important impact on the selectivity conditions for polymorphs, which is crucial in the production of pharmaceutical compounds. The project here will be to develop a microfluidic chip for crystallization, which consists in designing and fabricating the microfluidic chip by soft lithography and using high sensitive microscopy for characterization. This chip should allow determining the crystal solubility, controlling the shear stress from various flow structures and determining its influence on the germination kinetics and the morphological selection. The experimental study will be complemented with direct numerical simulations using dedicated CFD (Computational Fluid Dynamics) software’s.
Promoteur/Supervisor : Prof. Scheid Benoit
Email : bscheid@ulb.ac.be
Site Web/Web site :
Centre de recherche/Research center : TIPs
Faculté/Faculty : Faculté des Sciences appliquées - école polytechnique/Brussels School of Engineering (Faculty of Applied Sciences)
Ecole doctorale/Graduate Colleges : Sciences de l'ingénieur/Engineering
Ecole doctorale thématique/Graduate School (French Only): Phénomènes non-linéaires, systèmes complexes et mécanique statistique



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