In silico rational design of modified proteins

Abstract : Proteins carry out a large variety of biological functions in living organisms. Some proteins, for example, act as particularly specific and efficient catalysts. The possibility to exploit the functional properties of proteins in fundamental research or industrial applications (food industry, chemical processes, pharmaceutical developments, etc.) is extremely interesting; however, one of its major limitations is that proteins generally lose their stability and activity under non-physiological conditions, or present solubility problems. In particular, most proteins are able to carry out their activity only within a very narrow range of temperature. The ability to design modified proteins that remain structured and active at higher (or lower) temperatures and show an increased solubility is therefore an important objective of both fundamental and industrial research. The project consists of developing a computational approach to predict the changes in thermal stability and in solubility of proteins upon mutations on the basis of simplified representations of protein structure and statistical energy functions.
Promoteur/Supervisor : Prof. Gilis Dimitri
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Centre de recherche/Research center : 3BIO - BioModeling, BioInformatics & BioProcesses
Faculté/Faculty : Faculté des Sciences appliquées - école polytechnique/Brussels School of Engineering (Faculty of Applied Sciences)
Ecole doctorale/Graduate Colleges : Sciences agronomiques et ingénierie biolo/Agronomy and Bioengineering
Ecole doctorale thématique/Graduate School (French Only): Structure et fonction des macromolécules biologiques, bioinformatique et modélisation (SFMBBM)

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