Type 1 Diabetes - Basic Research


Abstract : Our research is focused on the clarification of the mechanisms of pancreatic β-cell dysfunction and death in type 1 diabetes (T1D) in order to devise novel ways to prevent immune-mediated β-cell loss. By using genomics, proteomics and detailed signal transduction analysis we contributed to the clarification of the molecular signalling involved in cytokine-mediated β-cell apoptosis and pro-inflammatory responses (Eizirik et al Diabetologia 2013; Vanzela & Cardozo Diabetologia 2012). We are now delineating the role of some key identified proteins in diabetes development both at the molecular level and in in vivo models of T1D.
Promoteur/Supervisor : Prof. Cardozo Alessandra K.
Email : akupperc@ulb.ac.be
Site Web/Web site : http://lmedex.ulb.ac.be
Centre de recherche/Research center : ULB Center for Diabetes Research
Faculté/Faculty : Faculty of Medicine/Faculté de Médecine
Ecole doctorale/Graduate Colleges : Biomedical and Pharmaceutical Science/Sciences biomédicales et pharmaceutiques
Ecole doctorale thématique/Graduate School (French Only): Biologie Cellulaire et Moléculaire, Biochimie (BCMB)



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