SIGNAL TRANSDUCTION IN METABOLIC DISEASES.


Abstract : The focus of our research is to understand the signalling pathways responsible for the development of diabetes. We study mechanisms of insulin-producing beta cell dysfunction and death in the pancreas and insulin resistance in the liver, muscle and white adipocyte tissue. The strength of the laboratory is the combined use of molecular biology, animal models of diabetes and human samples. In addition, we have designed new molecules that can be used in pre-clinical studies to measure beta cell mass for the early diagnosis of the disease. This work is carried out in the ULB Center for Diabetes Research, which provides an ideal environment, with a strong focus on autoimmune diabetes, as well as obesity and type 2 diabetes. We have also access to human samples for this project and a platform for immediate translation of the findings to patient care. We aim to make a difference to the millions of sufferers of diabetes by providing insights into ways that diabetes can be detected and treated. Selected Publications: 1. Litwak SA et al. JNK activation of BIM promotes hepatic oxidative stress, steatosis, and insulin resistance in obesity. Diabetes, on line (2017). 2. Gurzov EN et al. Protein tyrosine phosphatases: molecular switches in metabolism and diabetes. Trends in Endocrinology & Metabolism 26:30-9 (2015). 3. Gurzov EN, et al. Hepatic oxidative stress promotes insulin-STAT5 signaling and obesity by inactivating PTPN2. Cell Metabolism 20:85-102 (2014).
Promoteur/Supervisor : Prof. Gurzov Esteban
Email : egurzov@ulb.ac.be
Site Web/Web site : http://lmedex.ulb.ac.be
Centre de recherche/Research center : ULB Center for Diabetes Research
Faculté/Faculty : Faculty of Medicine/Faculté de Médecine
Ecole doctorale/Graduate Colleges : Biomedical and Pharmaceutical Science/Sciences biomédicales et pharmaceutiques
Ecole doctorale thématique/Graduate School (French Only): Médecine clinique et expérimentale



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