|Abstract : Group A streptococcus (GAS) infections, particularly rheumatic heart disease and invasive infection, are responsible for more than half a million deaths worldwide per year. With no effective control strategies available, a GAS vaccine is urgently needed. Based upon current understanding, the most promising vaccines are strain-specific (emm-type specific). However, the development of a global GAS vaccine is hindered by the large number of circulating emm-types especially in low income settings where serious GAS disease is most common.
Combined with the M protein, the M-like proteins (Mrp and Enn) may overcome the poor immunogenicity of the current vaccine candidates against specific groups of streptococcal strains that are associated with high disease burden in low-income settings. However the role of these two proteins in virulence is poorly characterized.
The main objective of this work is to elicit the role in virulence of the M-like proteins, focusing on Mrp and to study their potential use as a complementary antigen for efficient vaccine formulations in low-income settings. |
|Promoteur/Supervisor : Prof. Smeesters Pierre|
|Email : email@example.com|
|Site Web/Web site : https://www.ulb.ac.be/rech/inventaire/unites/ULB588.html|
|Centre de recherche/Research center : |
|Faculté/Faculty : Faculty of Medicine/Faculté de Médecine|
|Ecole doctorale/Graduate Colleges : Medical Science/Sciences médicales|
|Ecole doctorale thématique/Graduate School (French Only): |