neurogenetics of ageing

Abstract : The major research goal in our laboratory is to understand how - and why - neurons and behaviour evolves with the age of the animal. C. elegans is well suited to address this question: on top of its well characterised nervous system, the genetics of lifespan is well understood. Practically, It is easy to manipulate genetically and has a short lifespan and a transparent body, allowing optogenetic techniques over the lifespan of individuals. Several approaches are used in our lab including genetics, optogenetics, behaviour, and quantitative cell biology. Many signalling pathway regulating the ageing process were first identified in C. elegans, exemplified by the well-known and highly conserved insulin/IGF-1 pathway. Combining the functional imaging and the power of genetics in C. elegans should give us a powerful comprehensive vision of the physiological ageing of a nervous system.
Promoteur/Supervisor : Prof. Laurent Patrick
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Centre de recherche/Research center : lab of neurophysiologie / UNI
Faculté/Faculty : Faculty of Medicine/Faculté de Médecine
Ecole doctorale/Graduate Colleges : Biomedical and Pharmaceutical Science/Sciences biomédicales et pharmaceutiques
Ecole doctorale thématique/Graduate School (French Only): Neurosciences

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