|Abstract : The analysis of the tissue at the microscopic level is essential to validate the relevance of a radiotracer or the effect of a treatment. The major difficulty is to be able to match the in vivo anatomical (MRI,CT) or the functional (fMRI, PET, SPECT) image, with histological images obtained using whole slide imaging(WSI), which is becoming the standard for the Digital Pathology.
The project aims to map the data from these two levels of analysis (macro/micro).
These developments will help to validate the relevance of new PET tracers and new functional imaging methods (fMRI with or without contrast agent) by correlating the macroscopic imaging in vivo with detailed analysis at the histological level, notably through the use immunohistochemistry (IHC). IHC markers can target different functions involved in tumorigenesis and the effect of anti-tumor treatments, and the response of the host tissue, including specific markers of proliferation and death (apoptosis) cellular hypoxia, the angiogenesis and inflammation.|
|Promoteur/Supervisor : Prof. DEBEIR Olivier|
|Email : firstname.lastname@example.org|
|Site Web/Web site : |
|Centre de recherche/Research center : LISA & Center for Microscopy and Molecular Imaging|
|Faculté/Faculty : Brussels School of Engineering (Faculty of Applied Sciences)/Faculté des Sciences appliquées - école polytechnique|
|Ecole doctorale/Graduate Colleges : Engineering/Sciences de l'ingénieur|
|Ecole doctorale thématique/Graduate School (French Only): |