Relationship between Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder

Abstract : The attention deficit disorder/hyperactivity disorder(ADHD) and autism spectrum disorders (ASDS) are neurodevelopmental disorders considered as separate. Recent studies have yet put in perspective of clinical similarities at the level of their executive functions (FE) and social interactions (IS). The nature of the link between these disorders and the physiopathological mechanisms that underlie them remains relatively unexplored but nevertheless raises a question basic clinical for the optimization of the phenotypic characterization and the establishment of appropriate therapeutical strategies. Assumptions: Exploration of the qualitative/quantitative similarities/differences between these 2 disorders for the cognitive profiles and IS. Main Objectives Two steps 1) Characterisation of clinical profiles of FE and SI for 3 groups of children with ADHD, ASD (top level), ASD associated with ADHD. 2) In an original study we will perform between these 3 groups, a direct comparison of their functional brain maps acquired by fMRI, for two paradigms (inhibition and social exclusion), a comparison of the anatomical connectivity in DTI, and a comparison of brain volumes in anatomical MRI
Promoteur/Supervisor : Prof. MASSAT ISABELLE
Email :
Site Web/Web site :
Centre de recherche/Research center : Laboratory of Experimental Neurology
Faculté/Faculty : Faculty of Medicine/Faculté de Médecine
Ecole doctorale/Graduate Colleges : Medical Science/Sciences médicales
Ecole doctorale thématique/Graduate School (French Only): Neurosciences

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