Impact of the innate inflammatoy response induced during surgical resection on liver tumor growth.

Abstract : The liver is a frequent site of tumors development. Surgery plays a central role in the treatment of these cancers. During surgical resection of liver tumors, two phenomena are observed: 1) an acute inflammatory reaction induced by hepatic ischemia that causes tissue damage and can lead to early liver failure and 2) the regeneration of liver tissue to restore function and reduce the risk of liver failure in the long term. These two mechanisms may also influence in opposite ways the risk of tumor recurrence after surgery. Indeed, the cellular and molecular mediators involved in the inflammatory phase early in liver regeneration may stimulate or inhibit growth and migration of cancer cells. The aim of our work is to analyze the effects of ischemic injury and liver regeneration on tumor growth in a preclinical model of surgical liver metastasis resection of colon carcinoma in mice. The relationship between ischemia, regeneration and growth of liver tumors and the effects of modulation of these phenomena will be studied in transposable setting to the clinic. We will focus on the status of liver tumor-associated macrophages and myeloid-derived suppressive cells. The objective is to evaluate new therapeutic approaches that may improve the results of this surgery.
Promoteur/Supervisor : Prof. Flamand Véronique
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Site Web/Web site :
Centre de recherche/Research center : Institut d'Immunologie Médicale
Faculté/Faculty : Faculty of Medicine/Faculté de Médecine
Ecole doctorale/Graduate Colleges : Biomedical and Pharmaceutical Science/Sciences biomédicales et pharmaceutiques
Ecole doctorale thématique/Graduate School (French Only): Immunologie (EDIM)

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