Computational modeling of the molecular mechanism of circadian rhythms : links with physiological disorders.

Abstract : Circadian rhythms, with a period close to 24h, are observed in most living organisms and play a fundamental role in the adaptation of these organisms to their environment. Since several years, remarkable advances have permitted to largely unravel the molecular bases of circadian rhythms in various organisms, from plants to humans. Computational models were thus developped in order to analyze and clarify the regulatory network at the origin of circadian rhythms as well as the dynamical bases of physiological disorders associated with a dysfunction of the circadian clock. In humans, we mainly focus on the link between the circadian clock and sleep phase disorders, (bipolar or seasonal) depressions as well as the effect of jet lag and shift work. In plants, we investigate the effect of nutrition, and more particularly magnesium depletion, on the circadian rhythms of Arabidopsis. This latter study is based on computational approaches (in our Unit) combined with experimental approaches (in the Laboratory of Physiology and Molecular Genetics of Plants, ULB).
Promoteur/Supervisor : Prof. Leloup Jean-Christophe
Email :
Site Web/Web site :
Centre de recherche/Research center : Unit of Theoretical Chronobiology
Faculté/Faculty : Faculté des Sciences/Faculty of Sciences
Ecole doctorale/Graduate Colleges : Sciences/Science
Ecole doctorale thématique/Graduate School (French Only):

Retour à la liste principale/Back to main list