Molecular physiology of ion channels

Abstract : Ion channels are found in all living organisms. They play a key role in cell and organelle homeostasis, intracellular and intercellular signaling. Our research focuses on the molecular mechanisms underpinning the function and regulation of membrane ion channels. These questions are addressed using a multidisciplinary approach combining single channel electrophysiology and site-directed mutagenesis (molecular biology) for functional studies, FTIR-spectroscopic studies for structural studies, site-directed and computational studies to decipher at an atomic level the mechanisms of the permeation of inorganic ions and metabolites and the modeled interaction of channels with membrane lipids other proteins. Our current research topics focus on the transmembrane beta-barrel family such as mitochondrial VDAC channels and bacterial porins as well as on pore-forming peptides. In particular, we resort on mutagenesis to identify the residues of the protein that have a key role in selectivity towards inorganic ions and metabolites, in channel gating and voltage-dependence and to probe those that interact specifically with membrane lipids.
Promoteur/Supervisor : Prof. Homble Fabrice
Email :
Site Web/Web site :
Centre de recherche/Research center : Center for Structural Biology and Bioinformatics
Faculté/Faculty : Faculté des Sciences/Faculty of Sciences
Ecole doctorale/Graduate Colleges : Sciences/Science
Ecole doctorale thématique/Graduate School (French Only): Structure et fonction des macromolécules biologiques, bioinformatique et modélisation (SFMBBM)

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