|Abstract : Designing a drug with a therapeutic activity is a long and multi-disciplinary process. Currently the advent of a drug results from the work of synthesis chemists, biologists, spectroscopists, pharmacists and physicians. With the increase in the number of available targets (protein, nucleic acids) thanks to the deciphering of genomes and in the number of 3D structures of proteins computer-based methods are becoming a tool essential to accelerate drug discovery. We use these computer-assisted methods to conceive molecules able to modulate the activity of drug-targeted proteins (D-alanine:D-alanine ligase, myeloperoxidase).
|Promoteur/Supervisor : Prof. Prévost Martine|
|Email : email@example.com|
|Site Web/Web site : sfmb.ulb.ac.be|
|Centre de recherche/Research center : Structure et Fonction des Membranes Biologiques|
|Faculté/Faculty : Faculté des Sciences/Faculty of Sciences|
|Ecole doctorale/Graduate Colleges : Sciences/Science |
|Ecole doctorale thématique/Graduate School (French Only): |