Molecular Mechanism of Membrane Transporters


Abstract : Transmembrane transport proteins play a crucial role in all cells by conferring to plasma and internal membranes selective and regulated permeability to a wide range of ions and small molecules. Their dysfunction is the cause of an impressive list of diseases, and many are targets of drugs or pathogens. Transporters are working via a cycle of conformational changes that expose substrate-binding sites alternately to each side of the membrane. So far, a complete transport cycle has yet to be described as the alternate-mechanism provides only a rough description for transitions involved in the transport. In our group this dynamic process is being studied in bacterial amino acid transporters at the very microscopic level by long-term molecular dynamics simulations and molecular modeling. The proposed molecular mechanisms will be experimentally examined on homologous yeast permeases in the laboratory of Physiologie Moléculaire de la Cellule (ULB, Prof. B. André).
Promoteur/Supervisor : Prof. Prévost Martine
Email : mprevost@ulb.ac.be
Site Web/Web site : sfmb.ulb.ac.be
Centre de recherche/Research center : Structure et Fonction des Membranes Biologiques
Faculté/Faculty : Faculté des Sciences/Faculty of Sciences
Ecole doctorale/Graduate Colleges : Sciences/Science
Ecole doctorale thématique/Graduate School (French Only):



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