Gene regulation and signaling in immune responses

Abstract : The inflammatory response, elicited by pathogens or danger signals is critical for the initiation of immune responses. It involves molecules that will directly target infectious organisms and mediators such as chemokines and cytokines that will attract and educate other immune cells. This process has to be tightly controlled as acute inflammation can lead to tissue damage and chronic inflammatory states that are associated with a broad range of diseases, including autoimmunity, atherosclerosis and cancer. A few key cytokines that are expressed by activated macrophages and dendritic cells, including IL-12, IL-23 and IL-27 help dictate the type of adaptive immune response elicited in response to a pathogen. This project focuses on the control of cytokine production by innate cells. We study the implication of different mechanisms, including chromatin remodeling processes and mRNA destabilization. This project involves both in vitro molecular biology experiments and pre-clinical animal models.
Promoteur/Supervisor : Prof. GORIELY Stanislas
Email :
Site Web/Web site :
Centre de recherche/Research center : Institute for Medical Immunology
Faculté/Faculty : Faculté de Médecine/Faculty of Medicine
Ecole doctorale/Graduate Colleges : Sciences médicales/Medical Science
Ecole doctorale thématique/Graduate School (French Only): Immunologie (EDIM)

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