Mechanisms underlying the process of Epithelio-Mesenchymal Transition (EMT) in morphogenesis and mestastasis.


Abstract : Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cell layers lose polarity and cell-cell contacts, and undergo a dramatic remodeling of the cytoskeleton, converting adherent epithelial cells into individual migratory cells that can evade the extracellular matrix. EMTs are vital for morphogenesis, wound healing, tissue regeneration, organ fibrosis, and conversion of early tumors into invasive malignancies. Initially appreciated by embryologists, EMT is attracting increasing attention from oncologists. In many tumor types, EMT subgroups have been found that have a poor prognosis and are particularly resistant to therapy. At the molecular levels, genes that play key roles in embryonic development are frequently found to be culprits in cancer, and conversely, oncogenic genes are regularly reported as important factors in embryogenesis. As such, EMT is at the crossroads of multiple cellular processes but the molecular mechanisms underlying its genesis and regulation remain poorly understood. The main goal of our research is to screen and characterize novel EMT players that could potentially serve as “molecular signatures” in screen, diagnostic, prognostic and/or therapy of human malformations and genetic diseases. We use Xenopus embryos, cell lines and samples from tumor biobanks as model systems.
Promoteur/Supervisor : Prof. SOUOPGUI Jacob
Email : jsouopgu@ulb.ac.be
Site Web/Web site :
Centre de recherche/Research center : DBM-IBMM
Faculté/Faculty : FacultĂ© des Sciences/Faculty of Sciences
Ecole doctorale/Graduate Colleges : Sciences/Science
Ecole doctorale thématique/Graduate School (French Only): Biologie Cellulaire et MolĂ©culaire, Biochimie (BCMB)



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