|Abstract : Infrared imaging for the diagnostics of cancer in tissue sections
Our laboratory is performing intense research at the border between biophysics and medical research. We are a group of ca 40 researchers involved in protein research with an emphasis on membrane protein structure and function. We also apply infrared spectroscopy on cells and tissues to unravel the complexity of living systems.
Recently, arrays of detectors sensitive in the mid-infrared (4000-800 cm-1) became available, opening the possibility to record infrared images through a microscope where each pixel of the image is a full infrared spectrum. This spectrum contains a wealth of information about the biochemical nature of the cells and thereby about their nature.
Identifying cancer cells, cancer cell grade, and the various parameters of cancer environments is now becoming possible without staining and without antibodies. Hundreds of “markers” are immediately available in the infrared spectrum.
With the help of pathologists we are building database of spectra and images of cancer microtome sections. Changes as subtle as these found in the extracellular matrix, possibly related to cancer progression, could be imaged and different types of lymphocytes infiltrating the tumor could be identified
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|Promoteur/Supervisor : Prof. Goormaghtigh Erik|
|Email : firstname.lastname@example.org|
|Site Web/Web site : |
|Centre de recherche/Research center : Center for Structural Biology and Bioinformatics|
|Faculté/Faculty : Faculty of Sciences/Faculté des Sciences|
|Ecole doctorale/Graduate Colleges : Science/Sciences|
|Ecole doctorale thématique/Graduate School (French Only): Structure et fonction des macromolécules biologiques, bioinformatique et modélisation (SFMBBM)|