Discovery and study by proteomics and metabolomics of novel biomarkers related to neurodegenerative and systemic pathologies.

Abstract : We are developing a mass spectrometry/proteomics/metabolomics platform for fundamental and clinical research. In that context, we have discovered the respective ligand (and their post-translational modifications) for two distinct orphan G protein-coupled receptors, which are two chemoattractants for leukocytes, i.e. chemerin and F2L. In the present project, thanks to the recent development of novel state-of-the-art mass spectrometry strategies, we aim to improve the diagnosis and the prognosis of neurodegenerative diseases (multiple sclerosis, encephalitis, brain injury, epilepsy...): by comparing the proteomic and metabolomic profiles of cerebrospinal fluid and serum from patients, we aim to determine novel biomarker panels and their post-translational modifications, and so study their physiological roles. We also want to extend the strategy to systemic pathologies, such as idiopathic pulmonary fibrosis, rheumatoid arthritis, cancer. This project has the potential to elucidate the molecular causes, and improve the management, of devastating disorders. It will also serve to establish a combined proteomic and metabolomic mass spectrometry platform for body fluid and tissue analysis at the interface between clinical practice, laboratory medicine, and fundamental research, with potential applications in a wide array of neurological and non-neurological disorders (drug design, bioinformatics, microfluidics...).
Promoteur/Supervisor : Prof. Communi David
Email :
Site Web/Web site :
Centre de recherche/Research center : Mass Spectrometry and Proteomics lab. (IRIBHM)
Faculté/Faculty : Faculty of Medicine/Faculté de Médecine
Ecole doctorale/Graduate Colleges : Biomedical and Pharmaceutical Science/Sciences biomédicales et pharmaceutiques
Ecole doctorale thématique/Graduate School (French Only): Biologie Cellulaire et Moléculaire, Biochimie (BCMB)

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