Design, synthesis and pharmacological characterization of anticancer metal complexes

Abstract : Cancer is probably one of the most devastating diseases in the world. Despite the numerous drugs available and the efforts made to find new efficacious cures, it remains a major concern of public health. Among the anticancer agents classes metals and, especially, their complexes have been attracting much attention since the discovery of cisplatin by Barnett Rosenberg in the early 1970's. Up to now a large number of complexes have been synthesized and tested on cancer cells but finally the results are rather poor in terms of drug approval with only 3 Pt(II) complexes marketed worldwide. The subjects proposed in our research units are based on the design, synthesis and pharmacological evaluation of different type of transition metal complexes based upon these approaches : - cationic complexes, - water-soluble complexes, - complexes with additional biological properties, The tools we plan to use comprise : - organic synthesis of the ligands, - synthesis and full characterization of their complexes, - screening on a cancer cell lines, - biochemical/toxicological effects on cancer/normal cells, The core of the project is to achieve a rapid but thorough pharmacological and toxicological characterization of old and new complexes with most of the transition metals available to explore possible incomplete data about these potential new hits. ATTENTION : NO GRANT DIRECTLY AVAILABLE. THE CANDIDATE MUST FIRST APPLY FOR A GRANT (WORKING COSTS AND SALARY)!
Promoteur/Supervisor : Prof. Dufrasne François
Email :
Site Web/Web site :
Centre de recherche/Research center : Laboratory of Therapeutic Chemistry
Faculté/Faculty : Faculty of Pharmacy/Facult√© de Pharmacie
Ecole doctorale/Graduate Colleges : Biomedical and Pharmaceutical Science/Sciences biomédicales et pharmaceutiques
Ecole doctorale thématique/Graduate School (French Only): Sciences pharmaceutiques

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