Abstract : Our group studies the role and mechanisms of pancreatic beta cell dysfunction and apoptosis in the pathogenesis of monogenic and type 2 diabetes, in order to develop novel strategies to improve beta cell function and mass. The principle research topics are : * The study of the mechanisms of beta cell demise caused by adipocyte-derived factors in type 2 diabetes. The Cnop group has identified endoplasmic reticulum stress as an important cellular response contributing to free fatty acid-induced beta cell apoptosis. Using small molecules and RNA interference strategies to modulate the endoplasmic reticulum stress response, the Cnop group is elucidating the signal transduction by which free fatty acids induce beta cell apoptosis and identifying interesting therapeutic targets for the protection of beta cells in type 2 diabetes. * The pathogenesis of diabetes in patients with monogenic forms of diabetes due to mutations in genes that regulate endoplasmic reticulum stress signaling. * The pathogenesis of diabetes in Friedreich's ataxia, where mitochondrial dysfunction leads to beta cell demise. * The pathogenesis of diabetes in patients with loss-of-function of TRMT10A, a tRNA methyl transferase.
Promoteur/Supervisor : Prof. Cnop Miriam
Email : mcnop@ulb.ac.be
Site Web/Web site : http://lmedex.ulb.ac.be
Centre de recherche/Research center :
Faculté/Faculty : Faculté de Médecine/Faculty of Medicine
Ecole doctorale/Graduate Colleges : Sciences biomédicales et pharmaceutiques/Biomedical and Pharmaceutical Science
Ecole doctorale thématique/Graduate School (French Only):

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